Are Patrick Dempsey and Eric Dane Friends?

Patrick Dempsey is best known for his role as Derek Shepherd (or “McDreamy” as fans call him) and Eric Dane played Mark Sloan (better known as “McSteamy”) on the legendary ABC hit series Grey’s Anatomy. The show first aired in 2005 and is now the “longest-running medical drama on American television” — beating “ER,” which ran for 15 seasons, according to People. Though Grey’s Anatomy is still a smash hit and is now in its 19th season, Dane left the show in 2012 after his character Sloan died of complications in a plane crash, according to TVLine. “It was wonderful to work with and learn from a creative force like Shonda Rhimes,” he told the outlet.

Meanwhile, Dempsey left Grey’s Anatomy in 2012 when his character tragically died in a car accident. “It was just a natural progression of history,” he told Entertainment Weekly of his departure.

Though fans were dejected to see two main characters no longer part of such an iconic series, it’s safe to say that Dane and Dempsey have remained close friends even after their departure from Grey’s Anatomy.

Fans loved an Instagram photo of Eric Dane and Patrick Dempsey

When Patrick Dempsey and Eric Dane got back together, fans were there for it. The unexpected meeting came in the form of an Instagram photo showing the former “Grey’s Anatomy” co-stars standing oddly far apart – illustrating social distancing during the height of the COVID-19 pandemic. “Blurry image of hanging out 6ft apart,” Dane wrote in the April 2020 post. Though McSteamy provided useful information, fans were more excited to see the TV Doctors back together.

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“God I miss Mark and Derek,” one follower commented. “God, you two are such a big failure! Seeing Grays (again) and you’re both still in it…alive,” wrote another. Dane’s post also gained traction on Twitter, with over 5,000 retweets and thousands of comments from fans expressing how iconic this mashup was. “I didn’t mean to cry today but I think I have to,” wrote one Twitter user. “This is the best friendship ever,” tweeted another.

While it was refreshing to get the dynamic duo back together, fans of the show “Euphoria” have still demanded that Dempsey and Dane team up and appear on the series together.

‘Euphoria’ fans think Patrick Dempsey should have a cameo on the show

Eric Dane joined the cast of HBO’s hit series Euphoria as Cal Jacobs in 2019, and the show became a huge worldwide hit. According to Variety, “Euphoria” attracts millions of views per episode and is now HBO’s “second most-watched show” — catching up to “Game of Thrones,” which still sits at the top. Season 2 required viewers to delve deeper into Dane’s complex character, Cal, and the pivotal moments that shaped him when he was still a teenager, per Us Weekly. During those flashbacks, Cal shared a deep connection with his best friend, Derek , and fans are already suggesting Patrick Dempsey should play the role of Derek in the present in Euphoria.

Considering Mark Sloan and Derek Shepherd were best friends on Grey’s Anatomy, fans believe it’s only right that they reunite on Euphoria — and have high hopes it might happen. “Cal’s best friend to manifest to come back and it’s Patrick Dempsey,” one user tweeted. “Absolutely terrified ‘Euphoria’ will be casting Patrick Dempsey as old Derek,” wrote another.

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While the idea sounds pretty epic, Dane told E! News “Euphoria” creator Sam Levinson said the choice of the name Derek for his best friend and love interest was “purely coincidental.” As such, the possibility of Dempsey joining the cast or making a cameo on the show is slim to non-existent. But even if the two never return to the big screen together, they remain friends.